British journal of clinical pharmacology
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Br J Clin Pharmacol · Mar 2013
Randomized Controlled TrialThe efficacy of parecoxib on systemic inflammatory response associated with cardiopulmonary bypass during cardiac surgery.
Cardiopulmonary bypass (CPB) during cardiac surgery is well known to be associated with the development of a systemic inflammatory response. The efficacy of parecoxib in attenuating this systemic inflammatory response is still unknown. ⋯ Intra-operative parecoxib attenuated the systemic inflammatory response associated with CPB during cardiac surgery and lowered the biochemical markers of myocardial injury.