British journal of clinical pharmacology
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Br J Clin Pharmacol · Oct 2014
Randomized Controlled TrialEvaluation of the effect of naproxen on the pharmacokinetics and pharmacodynamics of apixaban.
To assess pharmacokinetic and pharmacodynamic interactions between naproxen (a non-steroidal anti-inflammatory drug) and apixaban (an oral, selective, direct factor-Xa inhibitor). ⋯ Co-administration of naproxen with apixaban results in higher apixaban exposure and appears to occur through increased apixaban bioavailability. The effects on anti-Xa activity, INR and inhibition of AAI-PA observed in this study were consistent with the individual pharmacologic effects of apixaban and naproxen.