British journal of clinical pharmacology
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Br J Clin Pharmacol · Jun 2014
Randomized Controlled TrialThe absolute bioavailability of racemic ketamine from a novel sublingual formulation.
The principal study objective was to investigate the pharmacokinetic characteristics of a new sublingual ketamine wafer and to establish its absolute bioavailability and local tolerability. ⋯ Sublingual administration of the ketamine wafer resulted in rapid absorption. The ketamine wafer has comparable bioavailability with other oral transmucosal formulations of ketamine but with markedly reduced inter-subject variability, warranting further evaluation as an analgesic adjunct.