British journal of clinical pharmacology
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Br J Clin Pharmacol · Oct 2015
Randomized Controlled Trial Multicenter StudyTreatment of spontaneous preterm labour with retosiban: a phase 2 proof-of-concept study.
The aim was to investigate the efficacy and safety of intravenous retosiban in women with spontaneous preterm labour. ⋯ Intravenous administration of retosiban in women with spontaneous preterm labour was associated with a greater than 1 week increase in time to delivery compared with placebo, a significant reduction in preterm deliveries, a non-significant increase in uterine quiescence and a favourable safety profile.