British journal of clinical pharmacology
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Br J Clin Pharmacol · Apr 2015
Randomized Controlled TrialSmall doses of droperidol do not present relevant torsadogenic actions: a double-blind, ondansetron-controlled study.
Drugs used for postoperative nausea and vomiting prophylaxis are believed to provoke torsadogenic changes in cardiac repolarization. The aim of this study was to assess the effect of small doses of droperidol on the parameters of cardiac repolarization, including the QTc interval and transmural dispersion of repolarization. ⋯ In men without cardiovascular disorders small doses (1.25 mg) of droperidol prophylaxis induced transient QTc prolongation without changes in transmural dispersion of repolarization. The apparently low risk of the drug applies only in low risk male patients with a low pro-QTc score.