Journal of neurosurgery
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Journal of neurosurgery · Jan 2005
The effect of gamma knife irradiation on functions of striatum in rats.
An animal model has been developed to study the effect of gamma knife surgery(GKS) on cerebral function. ⋯ Targeting by using the Régis-Valliccioni frame was very accurate compared with targeting with coordinates based on brain maps used hitherto. Although targeting improved the accuracy, further effort will still be necessary to reduce errors along dorsoventral axis. The apomorphine test indicated a reduced dopaminergic function of the irradiated area including striatum, which accompanied histological changes after a high dose of irradiation (150 Gy).
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Journal of neurosurgery · Jan 2005
Postoperative cerebral hyperperfusion associated with impaired cognitive function in patients undergoing carotid endarterectomy.
Cognitive impairment occurs in 20 to 30% of patients following carotid endarterectomy (CEA). The purpose of the present study was to determine whether postoperative cerebral hyperperfusion is associated with impairment of cognitive function in patients undergoing that procedure. ⋯ Postoperative cerebral hyperperfusion is associated with impairment of cognitive function in patients undergoing CEA. Furthermore, the development of hyperperfusion syndrome is associated with the persistence of postoperative cognitive impairment.
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Journal of neurosurgery · Jan 2005
Evaluation of a new concept for the management of skull base chordomas and chondrosarcomas.
Chordomas and chondrosarcomas of the skull base are rare locally invasive tumors associated with high recurrence rates. The aim of this study was to evaluate the concept of microsurgical tumor volume reduction followed by early gamma knife surgery (GKS). ⋯ Results of this treatment strategy are encouraging but the efficacy of this multimodal treatment combining surgery and early GKS requires a longer follow up.
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The purpose of this study was to assess the benefits of radiosurgery for cavernous hemangioma. ⋯ The authors found that GKS was an effective treatment modality for cavernous hemangiomas, especially for those located within the brainstem, basal ganglia, or deep portions of the brain. It can reduce seizure frequency significantly although this takes time. In the group receiving a marginal dose below 15 Gy the patients fared better than when the dose exceeded 15 Gy.
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Journal of neurosurgery · Jan 2005
Case ReportsGamma knife surgery for choroidal neovascularization in age-related macular degeneration. Technical note.
The authors conducted a study to determine a way of overcoming the poor-quality demonstration of choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) on conventional magnetic resonance (MR) imaging studies. The poor MR imaging demonstration of CNV in patients with AMD makes the use of gamma knife surgery more difficult. This difficulty, however, can be overcome by use of a modified time-of-flight MR imaging,sequence with Gd enhancement and coronal reconstruction.