Journal of neurosurgery
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Journal of neurosurgery · Jan 2005
Case ReportsTemporary symptomatic swelling of meningiomas following gamma knife surgery. Report of two cases.
In two patients in whom gamma knife surgery was performed for meningiomas clinically significant volume increases were observed in the first 3 months after treatment. Clinical examination and various imaging studies form the basis of the report in these patients. In each case, the volume increase was temporary.
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Journal of neurosurgery · Jan 2005
Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: outcomes and prognostic factors.
Lung carcinoma is the leading cause of death from cancer. More than 50% of those with small cell lung cancer develop a brain metastasis. Corticosteroid agents, radiotherapy, and resection have been the mainstays of treatment. Nonetheless, median survival for patients with small cell lung carcinoma metastasis is approximately 4 to 5 months after cranial irradiation. In this study the authors examine the efficacy of gamma knife surgery for treating recurrent small cell lung carcinoma metastases to the brain following tumor growth in patients who have previously undergone radiation therapy, and they evaluate factors affecting survival. ⋯ Stereotactic radiosurgery for recurrent small cell lung carcinoma metastases provided effective local tumor control in the majority of patients. Early detection of brain metastases, aggressive treatment of systemic disease, and a therapeutic strategy including radiosurgery can extend survival.
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Journal of neurosurgery · Jan 2005
Influence of endothelial nitric oxide synthase T-786C single nucleotide polymorphism on aneurysm size.
Among patients with aneurysms, those with heterozygous (T/C) endothelial nitric oxide synthase (eNOS) T-786C single nucleotide polymorphism (SNP), a mutation reducing endothelial nitric oxide synthesis, are reported to have larger ruptured intracranial aneurysms (IAs) than those with homozygous (C/C or T/T) genotype. The authors tested patients harboring aneurysms for eNOS T-786C SNP in two populations--Japanese and Korean. ⋯ The eNOS T-786C SNP genotype does not influence the size of aneurysms.
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Journal of neurosurgery · Jan 2005
Treatment of essential trigeminal neuralgia with gamma knife surgery.
The authors present the long-term follow-up results (minimum 5 years) of patients with essential trigeminal neuralgia (TN) who were treated with gamma knife surgery (GKS). ⋯ The initial success rate of pain relief was high and comparable to that reported in other studies. A higher than usual incidence of sensory impairment after GKS could be the long duration of follow-up study and due to the detailed neurological examination.
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Journal of neurosurgery · Jan 2005
Case ReportsGlossopharyngeal neuralgia treated with gamma knife surgery: treatment outcome and failure analysis. Case report.
Glossopharyngeal neuralgia (GPN) is a rare condition in which patients present with intractable deep throat pain. Similar to trigeminal neuralgia (TN), treatment with microvascular decompression (MVD) has been successful in both. Because gamma knife surgery (GKS) has also been shown to be effective in treating TN, it seemed reasonable to apply it to GPN. The authors present the first report of GKS-treated GPN in a patient who presented with severe, poorly controlled GPN and who refused MVD.