Journal of neurosurgery
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Journal of neurosurgery · Jan 2005
Gamma knife surgery for trigeminal neuralgia: improved initial response with two isocenters and increasing dose.
The authors sought to evaluate the initial response of trigeminal neuralgia (TN) to gamma knife surgery (GKS) based on the number of shots delivered and radiation dose. ⋯ Gamma knife surgery is an effective therapy for TN. Initial response rates appear to correlate with the number of shots and dose.
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Journal of neurosurgery · Jan 2005
Influence of endothelial nitric oxide synthase T-786C single nucleotide polymorphism on aneurysm size.
Among patients with aneurysms, those with heterozygous (T/C) endothelial nitric oxide synthase (eNOS) T-786C single nucleotide polymorphism (SNP), a mutation reducing endothelial nitric oxide synthesis, are reported to have larger ruptured intracranial aneurysms (IAs) than those with homozygous (C/C or T/T) genotype. The authors tested patients harboring aneurysms for eNOS T-786C SNP in two populations--Japanese and Korean. ⋯ The eNOS T-786C SNP genotype does not influence the size of aneurysms.
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Journal of neurosurgery · Jan 2005
Gamma knife surgery for brain metastases in patients harboring four or more lesions: survival and prognostic factors.
This study was performed to evaluate the role of gamma knife surgery (GKS) in patients with a large number (four or more) of metastatic brain lesions. ⋯ It is suggested that GKS provides an increase in survival time even in patients with a large number (four or more) of metastatic lesions. Concerning the selection of patients for GKS, RPA class should be considered as the most important factor and multiplicity of the lesions alone should not be a reason for withholding GKS.
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Journal of neurosurgery · Jan 2005
Case ReportsGamma knife surgery for choroidal neovascularization in age-related macular degeneration. Technical note.
The authors conducted a study to determine a way of overcoming the poor-quality demonstration of choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) on conventional magnetic resonance (MR) imaging studies. The poor MR imaging demonstration of CNV in patients with AMD makes the use of gamma knife surgery more difficult. This difficulty, however, can be overcome by use of a modified time-of-flight MR imaging,sequence with Gd enhancement and coronal reconstruction.
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The authors sought to evaluate local tumor control, complications, and progression-free survival in patients harboring low-grade gliomas who were treated with Leksell gamma knife surgery (GKS). ⋯ Relatively high local tumor control with minimal complications was achieved.