Journal of neurosurgery
-
Journal of neurosurgery · Jan 2005
Risk factors for aneurysmal subarachnoid hemorrhage in patients in Izumo City, Japan.
The annual incidence of aneurysmal subarachnoid hemorrhage (SAH) in Izumo City, Japan, appears to be the highest rate among those reported; therefore the author investigated the risk factors for SAH in patients in this city. ⋯ Among patients in Izumo, hypertension was the most notable risk factor for aneurysmal SAH, regardlessof age and sex, followed by cigarette smoking in younger men and hypercholesterolemia in older women. In older women, diabetes mellitus and heart disease decreased the risk of SAH.
-
Journal of neurosurgery · Jan 2005
The effect of gamma knife irradiation on functions of striatum in rats.
An animal model has been developed to study the effect of gamma knife surgery(GKS) on cerebral function. ⋯ Targeting by using the Régis-Valliccioni frame was very accurate compared with targeting with coordinates based on brain maps used hitherto. Although targeting improved the accuracy, further effort will still be necessary to reduce errors along dorsoventral axis. The apomorphine test indicated a reduced dopaminergic function of the irradiated area including striatum, which accompanied histological changes after a high dose of irradiation (150 Gy).
-
Journal of neurosurgery · Jan 2005
Early transplantation of an encapsulated glial cell line-derived neurotrophic factor-producing cell demonstrating strong neuroprotective effects in a rat model of Parkinson disease.
Glial cell line-derived neurotrophic factor (GDNF) has been shown to confer neuroprotective effects on dopaminergic neurons. The authors investigated the effects of GDNF on 6-hydroxydopamine (6-OHDA)-treated dopaminergic neurons in vitro and in vivo. ⋯ These neuroprotective effects may be related to glial proliferation and signaling via the GDNF receptor alpha1. The results of this study support a role for this grafting technique in the treatment of PD.