Journal of neurosurgery
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Journal of neurosurgery · Feb 2012
Multicenter Study Clinical TrialA multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depression.
Deep brain stimulation (DBS) has been recently investigated as a treatment for major depression. One of the proposed targets for this application is the subcallosal cingulate gyrus (SCG). To date, promising results after SCG DBS have been reported by a single center. In the present study the authors investigated whether these findings may be replicated at different institutions. They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression. ⋯ Overall, findings from this study corroborate the results of previous reports showing that outcome of SCG DBS may be replicated across centers.