Journal of neurosurgery
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Journal of neurosurgery · Sep 2014
Review Meta AnalysisThe efficacy of erythropoietin in treating experimental traumatic brain injury: a systematic review of controlled trials in animal models.
Erythropoietin (EPO) shows promise as a neuroprotective agent in animal models of traumatic brain injury (TBI). However, clinical trials of the efficacy of EPO treatment in patients with TBI yield conflicting results. The authors conducted a systematic review and meta-analysis to assess the effect of EPO in experimental animal models of TBI, the goal being to inform the design of future clinical trials. ⋯ Despite limitations of this systematic review that may have influenced the findings, the authors conclude that EPO might be beneficial in treating experimental TBI in terms of reducing lesion volume and improving neurobehavioral outcome. However, this review also indicates that more well-designed and well-reported animal studies are needed.
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Journal of neurosurgery · Sep 2014
Review Meta AnalysisChronic subdural hematoma: a systematic review and meta-analysis of surgical procedures.
In this paper the authors systematically evaluate the results of different surgical procedures for chronic subdural hematoma (CSDH). ⋯ Postoperative drainage has the advantage of reducing recurrence without increasing complications. The use of a bur hole or twist drill does not seem to make any significant difference in recurrence rates or other outcome measures. It seems that irrigation may lead to a better outcome. These results may lead to more standardized procedures.
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Journal of neurosurgery · Sep 2014
Review Meta AnalysisChronic subdural hematoma: a systematic review and meta-analysis of surgical procedures.
In this paper the authors systematically evaluate the results of different surgical procedures for chronic subdural hematoma (CSDH). ⋯ Postoperative drainage has the advantage of reducing recurrence without increasing complications. The use of a bur hole or twist drill does not seem to make any significant difference in recurrence rates or other outcome measures. It seems that irrigation may lead to a better outcome. These results may lead to more standardized procedures.
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Journal of neurosurgery · Sep 2014
Review Meta AnalysisDiagnostic accuracy of intraocular pressure measurement for the detection of raised intracranial pressure: meta-analysis: a systematic review.
Because clinical examination and imaging may be unreliable indicators of intracranial hypertension, intraocular pressure (IOP) measurement has been proposed as a noninvasive method of diagnosis. The authors conducted a systematic review and meta-analysis to determine the correlation between IOP and intracranial pressure (ICP) and the diagnostic accuracy of IOP measurement for detection of intracranial hypertension. ⋯ Although a modest aggregate correlation was found between IOP and ICP, the pooled diagnostic accuracy suggests that IOP measurement may be of clinical utility in the detection of intracranial hypertension. Given the significant heterogeneity between included studies, further investigation is required prior to the adoption of IOP in the evaluation of intracranial hypertension into routine practice.