Annals of the Royal College of Surgeons of England
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Ann R Coll Surg Engl · Sep 1984
Randomized Controlled Trial Comparative Study Clinical TrialEvaluation of anti-emetics in association with intrathecal diamorphine.
Intrathecal diamorphine is associated with a high incidence of emetic symptoms. Six anti-emetic drugs representing various chemical groups were given in random order to patients undergoing total hip replacement and who had received intrathecal diamorphine 0.5-1.0 mg. The phenothiazines, perphenazine and prochlorperazine, were more effective than the others. It is suggested that this might be a useful model for the evaluation of new anti-emetics.