British dental journal
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British dental journal · Nov 1999
Randomized Controlled Trial Comparative Study Clinical TrialCognitive properties of sedation agents: comparison of the effects of nitrous oxide and midazolam on memory and mood.
To compare the effects of nitrous oxide and midazolam on cognition and mood. ⋯ It is important for clinicians to be aware that peri-operative recall of information is reduced in patients who have undergone midazolam sedation. This is an advantage for patients who are anxious, and do not wish to be aware of the operative treatment being performed. However, as the cognitive impairment is enduring, an adult escort and written post-operative instructions should be mandatory for midazolam sedation patients. In contrast, the use of nitrous oxide sedation does not significantly impair higher cognitive tasks and thus patients receiving nitrous oxide sedation can resume normal activities in the post-operative period.