Drug and alcohol dependence
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Drug Alcohol Depend · Oct 2007
Randomized Controlled TrialSublingual buprenorphine/naloxone precipitated withdrawal in subjects maintained on 100mg of daily methadone.
Acute doses of buprenorphine can precipitate withdrawal in opioid dependent persons. The likelihood of this withdrawal increases as a function of the level of physical dependence. ⋯ There is considerable between subject variability in sensitivity to buprenorphine's antagonist effects. Low, repeated doses of buprenorphine/naloxone (e.g., 2mg/0.5mg) may be an effective mechanism for safely dosing this medication in persons with higher levels of physical dependence.