Drug and alcohol dependence
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Drug Alcohol Depend · Nov 2013
Randomized Controlled TrialEfficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial.
Tramadol is an atypical analgesic with monoamine and modest mu opioid agonist activity. The purpose of this study was to evaluate: (1) the efficacy of extended-release (ER) tramadol in treating prescription opioid withdrawal and (2) whether cessation of ER tramadol produces opioid withdrawal. ⋯ ER tramadol 200mg modestly attenuated opioid withdrawal. Mild opioid withdrawal occurred after cessation of treatment with 600 mg tramadol. These data support the continued investigation of tramadol as a treatment for opioid withdrawal.