Drug and alcohol dependence
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Drug Alcohol Depend · Feb 2013
Randomized Controlled TrialEpidemiology of pain among outpatients in methadone maintenance treatment programs.
This analysis explored the prevalence and correlates of pain in patients enrolled in methadone maintenance treatment (MMT). ⋯ Clinically significant pain was reported by almost half of the patients in MMT programs and was associated with medical and psychological comorbidity. Pain was often treated with opioids and was not associated with measures of drug use. Studies are needed to further clarify these associations and determine their importance for pain treatment strategies.
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Drug Alcohol Depend · Feb 2013
Randomized Controlled Trial Comparative StudyBuprenorphine/Naloxone and methadone effects on laboratory indices of liver health: a randomized trial.
Buprenorphine/naloxone (BUP) and methadone (MET) are efficacious treatments for opioid dependence, although concerns about a link between BUP and drug-induced hepatitis have been raised. This study compares the effects of BUP and MET on liver health in opioid-dependent participants. ⋯ This study demonstrated no evidence of liver damage during the initial 6 months of treatment in either condition. Physicians can prescribe either medication without major concern for liver injury.