The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Jun 2003
ReviewAntibiotics and hospital-acquired Clostridium difficile-associated diarrhoea: a systematic review.
A systematic review of studies that investigated the association of antibiotics with hospital-acquired Clostridium difficile-associated diarrhoea (CDAD) was undertaken to summarize the strength of the evidence for this relationship. The results from the studies identified were considered after critically reviewing the design and conduct of each study. ⋯ Two studies of reasonable quality suggested an association between clindamycin, cephalosporins, penicillins and CDAD. Well-designed studies grounded in epidemiological principles are needed to identify true risk factors for CDAD and to provide reliable estimates of the strength of association.