The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Dec 2004
Randomized Controlled Trial Multicenter Study Clinical TrialReduced colonization and infection with miconazole-rifampicin modified central venous catheters: a randomized controlled clinical trial.
Central venous catheters (CVC) are a major cause of nosocomial bloodstream infections. Catheters modified with miconazole and rifampicin that constantly and slowly release antimicrobial substances are assumed to be beneficial in reducing rates of colonization and catheter-related infections. ⋯ CVC supersaturated with miconazole and rifampicin were associated with a significantly lower risk for catheter colonization and catheter-related infections compared to standard catheters.