The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Feb 2007
Randomized Controlled TrialIs continuous infusion ceftriaxone better than once-a-day dosing in intensive care? A randomized controlled pilot study.
To compare the clinical and bacteriological outcome of critically ill patients with sepsis treated by ceftriaxone administered as a once-a-day intermittent bolus dose or by 24 h continuous infusion. ⋯ This pilot study suggests clinical and bacteriological advantages of continuous infusion of ceftriaxone over bolus administration in critically ill patients in patients requiring 4 or more days of treatment. This sets the scene for a large multicentre double-blind randomized controlled trial to confirm these findings.