The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Mar 2007
Meta AnalysisRifampicin-impregnated central venous catheters: a meta-analysis of randomized controlled trials.
The use of antimicrobial-impregnated central venous catheters (CVCs) for the prevention of CVC microbial colonization and catheter-related bloodstream infection (CRBSI) remains controversial. ⋯ The available evidence suggests that rifampicin/minocycline-impregnated CVCs are safe and effective in reducing the rate of catheter colonization and CRBSI. Further research should focus on the possible development of resistance and on pharmacoeconomic issues related to the use of rifampicin/minocycline-impregnated CVCs.