The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Jul 2009
Review Meta AnalysisAntibiotics versus placebo or watchful waiting for acute otitis media: a meta-analysis of randomized controlled trials.
Recommendations on withholding antibiotics in children with acute otitis media (AOM) have been inadequately implemented in clinical practice. ⋯ Antibiotic treatment is associated with a more favourable clinical course in children with AOM, compared with placebo, and also compared with watchful waiting. However, safety issues and the rather small treatment effect difference render the consideration of additional factors necessary in relevant clinical decision making.