The Journal of antimicrobial chemotherapy
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J. Antimicrob. Chemother. · Sep 1990
Randomized Controlled Trial Clinical Trial Controlled Clinical TrialPrevention of bacterial colonization of the respiratory tract and stomach of mechanically ventilated patients by a novel regimen of selective decontamination in combination with initial systemic cefotaxime.
A novel regimen of selective decontamination (SDD) with initial systemic cefotaxime prevented bacterial colonization of the oropharynx and stomach in mechanically ventilated patients. In a three-group study of all patients receiving prolonged mechanical ventilation, patients in control groups A and B received antibiotics only when infection was present. In group A, antibiotics that disturb colonization resistance (CR) were used. ⋯ In group C, only 12% and 24% of the patients acquired colonization of the oropharynx and stomach respectively (P less than 0.001). The oropharynx and stomach were the major sources of microorganisms causing lower respiratory tract infection in both control groups. In group C, elimination of oropharyngeal and gastric colonization completely prevented lower respiratory tract infection from these sources.
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J. Antimicrob. Chemother. · Sep 1983
Review Randomized Controlled Trial Comparative Study Clinical TrialInterim summary of mortality in herpes simplex encephalitis and neonatal herpes simplex virus infections: vidarabine versus acyclovir.
Herpes simplex encephalitis and neonatal herpes simplex virus infections are important consequences of herpes simplex virus infections of humans. The association of both diseases with significant mortality and morbidity has prompted intensive therapeutic trials designed to improve outcome. The NIAID Collaborative Antiviral Study Group has been able to demonstrate that vidarabine therapy decreases the mortality and improves morbidity for both herpes simplex encephalitis and neonatal herpes simplex virus infections. ⋯ Because adequate numbers of patients for definitive statistical analyses have not been entered into the trial, data were assessed according to outcome for the entire group, irrespective of drug administered. The mortality of herpes simplex encephalitis and neonatal herpes simplex virus infections has been reduced to 34 and 30%, respectively, a decrease of approximately 10% for each disease. Further analyses await completion of the trials.
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J. Antimicrob. Chemother. · Sep 1980
Randomized Controlled Trial Comparative Study Clinical TrialA double blind clinical trial of cefotaxime and cefazolin in complicated urinary tract infections.
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J. Antimicrob. Chemother. · Sep 1980
Randomized Controlled Trial Comparative Study Clinical TrialCefotaxime in lower respiratory tract infections compared to cefazolin.