Neuroscience letters
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Neuroscience letters · Feb 2004
Randomized Controlled Trial Clinical TrialRepetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome type I.
In complex regional pain syndrome (CRPS) many clinical symptoms suggest involvement of the central nervous system. Neuropathic pain as the leading symptom is often resistant to therapy. In the present study we investigated the analgesic efficiency of repetitive transcranial magnetic simulation (rTMS) applied to the motor cortex contralateral to the CRPS-affected side. ⋯ Pain re-intensified increasingly 45 min after rTMS. In contrast, sham rTMS did not alter pain perception. These findings provide evidence that in CRPS I pain perception can be modulated by repetitive motor cortex stimulation.