The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus.
Controversy exists about the best surgical treatment for esophageal carcinoma. ⋯ Transhiatal esophagectomy was associated with lower morbidity than transthoracic esophagectomy with extended en bloc lymphadenectomy. Although median overall, disease-free, and quality-adjusted survival did not differ statistically between the groups, there was a trend toward improved long-term survival at five years with the extended transthoracic approach.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Dexamethasone in adults with bacterial meningitis.
Mortality and morbidity rates are high among adults with acute bacterial meningitis, especially those with pneumococcal meningitis. In studies of bacterial meningitis in animals, adjuvant treatment with corticosteroids has beneficial effects. ⋯ Early treatment with dexamethasone improves the outcome in adults with acute bacterial meningitis and does not increase the risk of gastrointestinal bleeding.