The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer.
On the basis of a previous meta-analysis, the International Adjuvant Lung Cancer Trial was designed to evaluate the effect of cisplatin-based adjuvant chemotherapy on survival after complete resection of non-small-cell lung cancer. ⋯ Cisplatin-based adjuvant chemotherapy improves survival among patients with completely resected non-small-cell lung cancer.
-
Randomized Controlled Trial Clinical Trial
A trial of antiparasitic treatment to reduce the rate of seizures due to cerebral cysticercosis.
Neurocysticercosis is the main cause of adult-onset seizures in the developing world. Whether therapy with antiparasitic agents results in improved seizure control has been questioned because of the lack of adequate, controlled studies. ⋯ In patients with seizures due to viable parenchymal cysts, antiparasitic therapy decreases the burden of parasites and is safe and effective, at least in reducing the number of seizures with generalization.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease.
Restenosis after coronary stenting necessitates repeated percutaneous or surgical revascularization procedures. The delivery of paclitaxel to the site of vascular injury may reduce the incidence of neointimal hyperplasia and restenosis. ⋯ As compared with bare-metal stents, the slow-release, polymer-based, paclitaxel-eluting stent is safe and markedly reduces the rates of clinical and angiographic restenosis at nine months.
-
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation.
Vasopressin is an alternative to epinephrine for vasopressor therapy during cardiopulmonary resuscitation, but clinical experience with this treatment has been limited. ⋯ The effects of vasopressin were similar to those of epinephrine in the management of ventricular fibrillation and pulseless electrical activity, but vasopressin was superior to epinephrine in patients with asystole. Vasopressin followed by epinephrine may be more effective than epinephrine alone in the treatment of refractory cardiac arrest.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Efficacy and safety of low-dose aspirin in polycythemia vera.
The use of aspirin for the prevention of thrombotic complications in polycythemia vera is controversial. ⋯ Low-dose aspirin can safely prevent thrombotic complications in patients with polycythemia vera who have no contraindications to such treatment.