The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Excision margins in high-risk malignant melanoma.
Controversy exists concerning the necessary margin of excision for cutaneous melanoma 2 mm or greater in thickness. ⋯ A 1-cm margin of excision for melanoma with a poor prognosis (as defined by a tumor thickness of at least 2 mm) is associated with a significantly greater risk of regional recurrence than is a 3-cm margin, but with a similar overall survival rate.
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Randomized Controlled Trial Clinical Trial
Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea.
B-type natriuretic peptide levels are higher in patients with congestive heart failure than in patients with dyspnea from other causes. ⋯ Used in conjunction with other clinical information, rapid measurement of B-type natriuretic peptide in the emergency department improved the evaluation and treatment of patients with acute dyspnea and thereby reduced the time to discharge and the total cost of treatment.