The New England journal of medicine
-
Multicenter Study
Survival of patients with stage I lung cancer detected on CT screening.
The outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) is unknown. ⋯ Annual spiral CT screening can detect lung cancer that is curable.
-
Randomized Controlled Trial Multicenter Study
D-dimer testing to determine the duration of anticoagulation therapy.
The optimal duration of oral anticoagulation in patients with idiopathic venous thromboembolism is uncertain. Testing of D-dimer levels may play a role in the assessment of the need for prolonged anticoagulation. ⋯ Patients with an abnormal D-dimer level 1 month after the discontinuation of anticoagulation have a significant incidence of recurrent venous thromboembolism, which is reduced by the resumption of anticoagulation. The optimal course of anticoagulation in patients with a normal D-dimer level has not been clearly established. (ClinicalTrials.gov number, NCT00264277 [ClinicalTrials.gov].).
-
Randomized Controlled Trial Multicenter Study Comparative Study
Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis.
Carotid stenting is less invasive than endarterectomy, but it is unclear whether it is as safe in patients with symptomatic carotid-artery stenosis. ⋯ In this study of patients with symptomatic carotid stenosis of 60% or more, the rates of death and stroke at 1 and 6 months were lower with endarterectomy than with stenting. (ClinicalTrials.gov number, NCT00190398 [ClinicalTrials.gov].).
-
Randomized Controlled Trial Multicenter Study
Effect of ramipril on the incidence of diabetes.
Previous studies have suggested that blockade of the renin-angiotensin system may prevent diabetes in people with cardiovascular disease or hypertension. ⋯ Among persons with impaired fasting glucose levels or impaired glucose tolerance, the use of ramipril for 3 years does not significantly reduce the incidence of diabetes or death but does significantly increase regression to normoglycemia. (ClinicalTrials.gov number, NCT00095654 [ClinicalTrials.gov].).
-
Randomized Controlled Trial Multicenter Study
Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease.
Second-generation (atypical) antipsychotic drugs are widely used to treat psychosis, aggression, and agitation in patients with Alzheimer's disease, but their benefits are uncertain and concerns about safety have emerged. We assessed the effectiveness of atypical antipsychotic drugs in outpatients with Alzheimer's disease. ⋯ Adverse effects offset advantages in the efficacy of atypical antipsychotic drugs for the treatment of psychosis, aggression, or agitation in patients with Alzheimer's disease. (ClinicalTrials.gov number, NCT00015548 [ClinicalTrials.gov].).