The New England journal of medicine
-
Randomized Controlled Trial Multicenter Study Comparative Study
Laparotomy versus peritoneal drainage for necrotizing enterocolitis and perforation.
Perforated necrotizing enterocolitis is a major cause of morbidity and mortality in premature infants, and the optimal treatment is uncertain. We designed this multicenter randomized trial to compare outcomes of primary peritoneal drainage with laparotomy and bowel resection in preterm infants with perforated necrotizing enterocolitis. ⋯ The type of operation performed for perforated necrotizing enterocolitis does not influence survival or other clinically important early outcomes in preterm infants. (ClinicalTrials.gov number, NCT00252681.).
-
Randomized Controlled Trial Multicenter Study Comparative Study
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury.
The balance between the benefits and the risks of pulmonary-artery catheters (PACs) has not been established. ⋯ PAC-guided therapy did not improve survival or organ function but was associated with more complications than CVC-guided therapy. These results, when considered with those of previous studies, suggest that the PAC should not be routinely used for the management of acute lung injury. (ClinicalTrials.gov number, NCT00281268.).
-
Editorial Comment
Necrotizing enterocolitis in preterm infants--is laparotomy necessary?
-
Editorial Comment Historical Article
Pulmonary-artery catheters--peace at last?