The New England journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Vasopressin versus norepinephrine infusion in patients with septic shock.
Vasopressin is commonly used as an adjunct to catecholamines to support blood pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors. ⋯ Low-dose vasopressin did not reduce mortality rates as compared with norepinephrine among patients with septic shock who were treated with catecholamine vasopressors. (Current Controlled Trials number, ISRCTN94845869 [controlled-trials.com].).
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Editorial Comment
Septic shock--vasopressin, norepinephrine, and urgency.
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Single-nucleotide polymorphisms (SNPs) in five chromosomal regions--three at 8q24 and one each at 17q12 and 17q24.3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger. ⋯ SNPs in five chromosomal regions plus a family history of prostate cancer have a cumulative and significant association with prostate cancer.