The New England journal of medicine
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Editorial Comment
A common genetic mechanism in malignant bone marrow diseases.
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Randomized Controlled Trial Multicenter Study
Radiofrequency ablation in Barrett's esophagus with dysplasia.
Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma. We assessed whether endoscopic radiofrequency ablation could eradicate dysplastic Barrett's esophagus and decrease the rate of neoplastic progression. ⋯ In patients with dysplastic Barrett's esophagus, radiofrequency ablation was associated with a high rate of complete eradication of both dysplasia and intestinal metaplasia and a reduced risk of disease progression. (ClinicalTrials.gov number, NCT00282672.)
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The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. The mechanisms underlying these disorders are not well defined. ⋯ Somatic mutations in TET2 occur in about 15% of patients with various myeloid cancers.