The New England journal of medicine
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Randomized Controlled Trial Multicenter Study
Abiraterone and increased survival in metastatic prostate cancer.
Biosynthesis of extragonadal androgen may contribute to the progression of castration-resistant prostate cancer. We evaluated whether abiraterone acetate, an inhibitor of androgen biosynthesis, prolongs overall survival among patients with metastatic castration-resistant prostate cancer who have received chemotherapy. ⋯ The inhibition of androgen biosynthesis by abiraterone acetate prolonged overall survival among patients with metastatic castration-resistant prostate cancer who previously received chemotherapy. (Funded by Cougar Biotechnology; COU-AA-301 ClinicalTrials.gov number, NCT00638690.).
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Randomized Controlled Trial
Effect of bronchoconstriction on airway remodeling in asthma.
Asthma is characterized pathologically by structural changes in the airway, termed airway remodeling. These changes are associated with worse long-term clinical outcomes and have been attributed to eosinophilic inflammation. In vitro studies indicate, however, that the compressive mechanical forces that arise during bronchoconstriction may induce remodeling independently of inflammation. We evaluated the influence of repeated experimentally induced bronchoconstriction on airway structural changes in patients with asthma. ⋯ Bronchoconstriction without additional inflammation induces airway remodeling in patients with asthma. These findings have potential implications for management.
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Editorial Comment
Expanding treatment options for metastatic prostate cancer.