International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Nov 2004
Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer.
Hypofractionated stereotactic radiotherapy (SRT) for Stage I non-small-cell lung cancer requires that meticulous attention be paid toward ensuring optimal target definition. Two computed tomography (CT) scan techniques for defining internal target volumes (ITV) were evaluated. ⋯ Individualized ITVs can improve target definition for SRT of Stage I non-small-cell lung cancer, and use of only a single CT scan with a 10-mm margin is inappropriate. A single 4D scan generates comparable or larger ITVs than are generated using six unmonitored rapid CT scans, a finding related to the ability to account for all respiration-correlated mobility.
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Int. J. Radiat. Oncol. Biol. Phys. · Nov 2004
Long-term results using local excision after preoperative chemoradiation among selected T3 rectal cancer patients.
To assess the pelvic failure among patients with T3 rectal cancer treated with local excision after preoperative chemoradiation. ⋯ In an experience stimulated by patient refusal of APR, highly selected patients who responded well to conventional external-beam radiotherapy (CXRT) were selected to undergo local excision. Most of these patients had pathologic complete response. Local control and survival rates are comparable to those achieved with chemoradiation followed by mesorectal excision. This strategy should be prospectively studied in a group of patients with low rectal cancer who have no clinical evidence of tumor after chemoradiation.
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Int. J. Radiat. Oncol. Biol. Phys. · Nov 2004
Reproducibility of organ position using voluntary breath-hold method with spirometer for extracranial stereotactic radiotherapy.
To evaluate in healthy volunteers the reproducibility of organ position using a voluntary breath-hold method with a spirometer and the feasibility of this method for extracranial stereotactic radiotherapy in a clinical setting. ⋯ The voluntary breath-hold method with a spirometer is feasible, with relatively good reproducibility. We are encouraged about the use of this technique clinically for extracranial stereotactic radiotherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · Nov 2004
Practice Guideline GuidelineProposed guidelines for image-based intracavitary brachytherapy for cervical carcinoma: report from Image-Guided Brachytherapy Working Group.
To present issues to be considered in, and make proposals for, image-based brachytherapy for cervical cancer. ⋯ Although current institutional brachytherapy prescription for cervical cancer should continue, image-based data collection and analysis are needed to optimize cervical cancer brachytherapy. Proposals are made for research in image-based brachytherapy for cervical cancer.
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To investigate and compare the biologically effective doses, equivalent doses in 2-Gy fractions, log tumor cells killed, and late effects that can be estimated for the large fractions in short overall times that are now being delivered in various clinically used schedules in several countries for the treatment of cancer in human lungs, liver, and kidney. ⋯ Such large doses can apparently be given, with suitable precautions and experience. Ongoing clinical trials from an increasing number of centers will be reporting the results of tumor control and complications from this new modality of biologically higher doses.