International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Clinical TrialIntensity-modulated radiotherapy for resected mesothelioma: the Duke experience.
To assess the safety and efficacy of intensity-modulated radiotherapy (IMRT) after extrapleural pneumonectomy for malignant pleural mesothelioma. ⋯ With limited follow-up, 45-Gy IMRT provides reasonable local control for mesothelioma after extrapleural pneumonectomy. However, treatment-related pulmonary toxicity remains a significant concern. Care should be taken to minimize the dose to the remaining lung to achieve an acceptable therapeutic ratio.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Three-dimensional motion of liver tumors using cine-magnetic resonance imaging.
To measure the three-dimensional motion of liver tumors using cine-magnetic resonance imaging (MRI) and compare it to the liver motion assessed using fluoroscopy. ⋯ The results of our study have shown that cine-MRI can be used to directly assess liver tumor motion in three dimensions. Tumor motion did not correlate well with the diaphragm motion measured using kilovoltage fluoroscopy. The tumor motion data from cine-MRI can be used to facilitate individualized planning target volume margins to account for breathing motion.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Multicenter StudyRadiotherapy to improve local control regardless of surgical margin and malignancy grade in extremity and trunk wall soft tissue sarcoma: a Scandinavian sarcoma group study.
Adjuvant radiotherapy has during the past decades become increasingly used in the treatment of localized soft tissue sarcoma. We evaluated the effect of radiotherapy (RT) on local recurrence rates (LRRs) in Scandinavia between 1986 and 2005. ⋯ The results of our study have shown that adjuvant RT effectively prevents local recurrence in soft tissue sarcoma, irrespective of the tumor depth, malignancy grade, and surgical margin status. The effect was most pronounced in deep-seated, high-grade tumors, even when removed with a wide surgical margin.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Clinical TrialDosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases.
To investigate the dosimetric effects of translational and rotational patient positioning errors on the treatment of spinal and paraspinal metastases using computed tomography image-guided stereotactic body radiotherapy. The results of this study provide guidance for the treatment planning process and recognition of the dosimetric consequences of daily patient treatment setup errors. ⋯ For the best dosimetric results, spinal stereotactic treatments should have setup translational errors of < or =1 mm and rotational errors of < or =2 degrees .
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2008
Comparative StudyProton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons.
To report preliminary clinical outcomes for pediatric patients treated with proton beam radiation for intracranial ependymoma and compare the dose distributions of intensity-modulated radiation therapy with photons (IMRT), three-dimensional conformal proton radiation, and intensity-modulated proton radiation therapy (IMPT) for representative patients. ⋯ Preliminary disease control with proton therapy compares favorably with the literature. Dosimetric comparisons show the advantage of proton radiation compared with IMRT in the treatment of ependymoma. Further sparing of normal structures appears possible with IMPT. Superior dose distributions were accomplished with fewer beam angles with the use of protons and IMPT.