Neuroscience
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Cortical inhibitory interneurons have a wide range of important functions, including balancing network excitation, enhancing spike-time precision of principal neurons, and synchronizing neural activity within and across brain regions. All these functions critically depend on the integration of synaptic inputs in their dendrites. But the sparse number of inhibitory cells, their small caliber dendrites, and the problem of cell-type identification, have prevented fast progress in analyzing their dendritic properties. ⋯ Accumulating evidence indicates that the biophysical properties of inhibitory neuron dendrites differ substantially from those of pyramidal neurons. In addition to the supralinear dendritic integration commonly observed in pyramidal neurons, interneuron dendrites can also integrate synaptic inputs in a linear or sublinear fashion. In this comprehensive review, we compare the dendritic biophysical properties of the three major classes of cortical inhibitory neurons and discuss how these cell type-specific properties may support their functions in the cortex.
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Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory event or encounter with an object involves a distinct combination of physical energy sources impinging upon receptors. In the rodent whisker system, each primary afferent neuron located in the trigeminal ganglion innervates and responds to a single whisker and encodes a distinct set of physical stimulus properties - features - corresponding to changes in whisker angle and shape and the consequent forces acting on the whisker follicle. ⋯ Cortical neurons respond to more complex stimulus properties - such as correlated motion across whiskers - than those at early subcortical stages. Temporal integration along the pathway is comparatively weak: neurons up to barrel cortex (BC) are sensitive mainly to fast (tens of milliseconds) fluctuations in whisker motion. The topographic organization of whisker sensitivity is paralleled by systematic organization of neuronal selectivity to certain other physical features, but selectivity to touch and to dynamic stimulus properties is distributed in "salt-and-pepper" fashion.
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Rodents use an array of long tactile facial hairs, the vibrissae, to locate and discriminate objects. Each vibrissa is densely innervated by multiple different types of trigeminal (TG) sensory neurons. ⋯ There is a clear missing link between the morphologically defined neuronal types and their exact physiological properties and functions. We briefly summarize recent advances and consider single-cell transcriptome profiling, together with optogenetics-assisted in vivo electrophysiology, as a way to fill this major gap in our knowledge of the vibrissa sensory system.
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Our daily life consists of a continuous interplay between incoming sensory information and outgoing motor plans. Particularly during goal-directed behavior and active exploration of the sensory environment, brain circuits are merging sensory and motor signals. ⋯ The somatosensory (tactile) system is an attractive modality to study sensorimotor integration in health and disease, motivated by the need for revolutionary technology that builds upon conceptual understanding of sensorimotor integration, such as brain-machine-interfaces and neuro-prosthetics. In this perspective, we focus on the rat whisker system and put forward the posterior parietal cortex as a potential circuit where sensorimotor integration could occur during active somatosensation.
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The question of what function is served by the cortical column has occupied neuroscientists since its original description some 60years ago. The answer seems tractable in the somatosensory cortex when considering the inputs to the cortical column and the early stages of information processing, but quickly breaks down once the multiplicity of output streams and their sub-circuits are brought into consideration. ⋯ In particular, layer 5 RS cells employ noise reduction and homeostatic plasticity mechanism to preserve and even increase information transfer, while IB cells use more conventional Hebbian mechanisms to achieve a similar outcome. It is proposed that the rodent analog of the dorsal and ventral streams, a division reasonably well established in primate cortex, might provide a further level of organization for RS cell function and hence sub-circuit specialization.