Neuroscience
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Opioid prescription and illegal use have been soaring, and it has become a global concern. Adolescence, as a critical developmental period, is radically influenced by drug exposure. In the recent decade, transgenerational effects of paternal environmental exposure have been given greater consideration. ⋯ Moreover, the duration of action potentials decreased in morphine sired animals. Besides, the coefficient of variation of interspike intervals increased in morphine sired animals compared to the saline sired ones. Overall, the altered electrophysiological properties observed in this study may suggest a functional enhancement of Ca2+ activated K+ channels in LC neurons of morphine sired animals.