Neuroscience
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The study of the effects of fear and disgust on the capture of automatic attention is gaining interest. Most findings reveal a more efficient capture of exogenous attention by disgust than by fear stimuli, although the underlying mechanisms are not completely understood. The manipulation of their spatial frequency may provide new insight that may contribute to clarify this issue. ⋯ The results showed that disgust and fear distractors captured exogenous attention equally early, as indicated by the augmented amplitude of the N2p, and later disgust distractors are the ones eliciting the highest amplitude of the LPP component. While in an initial stage, both stimuli seem to have similar preferential access to further processing allowing fast responding in both cases, disgust is more deeply processed at a later stage probably facilitating its examination. These findings suggest that exploring the temporal course of processing is relevant for the understanding of the differential capture of exogenous attention by disgust and fear distractors.
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Randomized Controlled Trial
Greater cortical activation and motor recovery following mirror therapy immediately after peripheral nerve repair of the forearm.
Cortical reorganization occurs immediately after peripheral nerve injury, and early sensorimotor training is suggested during nerve regeneration. The effect of mirror therapy and classical sensory relearning on cortical activation immediately after peripheral nerve repair of the forearm is unknown. Six participants were randomly assigned to the mirror-therapy group or the sensory-relearning group. ⋯ All participants showed improvement in the SWM, S-2PD tests, upper extremity function, and grip strength after the intervention at T1, except for the participant who injured both the median and ulnar nerves in the sensory-relearning group. In addition, the mirror-therapy group had better outcomes in finger dexterity and manual dexterity, and fMRIs showed greater activation in the multimodal association cortices and ipsilateral brain areas during motor tasks. This study provides evidence-based results confirming the benefits of early sensorimotor relearning for cortical activation in peripheral nerve injury of the forearm and different neuroplasticity patterns between mirror therapy and classical sensor relearning.
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Procrastination is generally recognized as a problematic behavior and the consequences of which spread to various aspects of an individual's life such as academic performance, social accomplishment, well-being, and health. Previous studies have indicated that neuroticism is positively correlated with procrastination; however, little is known about the neural substrates underlying the link between neuroticism and procrastination. To address this issue, we employed voxel-based morphometry (VBM) and resting-state functional connectivity (RSFC) methods to investigate the neural underpinning for their relationship in the present study (N = 153). ⋯ Moreover, results from RSFC analysis suggested that the functional connectivity between RMTG and the right superior frontal gyrus (RSFG) was positively associated with neuroticism. More importantly, a mediation analysis demonstrated that neuroticism played a full mediating role in the impact of RMTG-RSFG functional connectivity on procrastination. Overall, the present study offered new insights into the relation between neuroticism and procrastination from a neural basis perspective, which also suggested the importance of emotional regulation with regard to the link between such an association.
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Central poststroke pain (CPSP) is a neuropathic pain syndrome that usually occurs after cerebrovascular accidents. Currently, the pathogenesis of CPSP is not fully understood. Purinergic P2X4 receptor (P2X4R) is implicated in neuropathic pain including CPSP. ⋯ This mechanism was associated with P2X4R expression and involved the endogenous opioid system. Human patients with CPSP showed decreased plasma levels of miR-133b-3p compared with those of control participants. Logistic regression analysis of our patient cohort showed that determining plasma levels of miR-133b-3p may be useful for CPSP diagnosis and treatment.
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Identifying printed words and pictures concurrently is ubiquitous in daily tasks, and so it is important to consider the extent to which reading words and naming pictures may share a cognitive-neurophysiological functional architecture. Two functional magnetic resonance imaging (fMRI) experiments examined whether reading along the left ventral occipitotemporal region (vOT; often referred to as a visual word form area, VWFA) has activation that is overlapping with referent pictures (i.e., both conditions significant and shared, or with one significantly more dominant) or unique (i.e., one condition significant, the other not), and whether picture naming along the right lateral occipital complex (LOC) has overlapping or unique activation relative to referent words. ⋯ Experiment 2 controlled for visual complexity by superimposing the words and pictures and instructing participants to either name the word or the picture, and showed primarily shared activation in the VWFA and LOC regions for both word reading and picture naming, with some dominant activation for pictures in the LOC. Overall, these results highlight the importance of including exception words to force lexical reading when comparing to picture naming, and the significant shared activation in VWFA and LOC serves to challenge specialized models of reading or picture naming.