Neuroscience
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Insect research has significantly advanced neuroscience by addressing fundamental questions, with groundbreaking discoveries emerging from research carried out in Uruguay. Powered by technological advances, the field has seen milestones in ultrastructure, neuronal and synaptic structure, and complex behavioral findings. Key contributions include the first formal description of chemical synapses, the identification of synaptic vesicle origins in the endoplasmic reticulum, and pioneering work on eye induction and development. ⋯ This review highlights four decades of Uruguayan legacy in insect neuroscience, underscoring how a small, yet vibrant, community of researchers has embraced interdisciplinary collaborations and innovative methodologies. Additionally, this review addresses the evolving role of women in the field and the collaborative spirit that has propelled scientific discovery, marking a critical juncture in the development of insect neuroscience. Despite limited resources, Uruguay has played a pivotal role in advancing our understanding of brain organization, neuronal-glial interactions, and connectomics, making lasting contributions to both local and global neuroscience.
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The neuropathologic mechanisms of sudden sensorineural hearing loss (SSNHL) are unknown. The aim of this study was to investigate the alterations of neurovascular coupling (NVC) in patients with SSNHL and its association with hematologic inflammatory factors. ⋯ From the view of the NVC metrics, these findings provide new perspectives on the neuropathologic mechanisms and clinical treatment of SSNHL.
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L-proline is an amino acid with a unique cyclic structure, involvement in various physiological processes, such as protein synthesis, collagen production, and neurotransmission. This review explores the complex roles of proline in the central nervous system (CNS), where it contributes to both excitatory and inhibitory neurotransmission. Additionally, L-proline has distinct metabolic functions attributed to its structural properties. ⋯ Studies in animal models suggest that L-proline influences cognitive function and behavior, with dysregulated levels linked to learning and memory deficits. Furthermore, this review addresses the neuropathological consequences of hyperprolinemia, a metabolic disorder marked by elevated L-proline levels in the CNS and examines the potential role of L-proline in neurological and psychiatric disorders. In sum, this work provides a comprehensive perspective on the neurobiological importance of L-proline, underscoring its involvement in neurotransmission, behavioral modulation, and disease pathology.