Neuroscience
-
Randomized Controlled Trial
Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: a BOLD and perfusion MRI study.
In young individuals, caffeine-mediated blockade of adenosine receptors and vasoconstriction has direct repercussions on task-related activations, changes in functional connectivity, as well as global vascular effects. To date, no study has explored the effect of caffeine on brain activation patterns during highly demanding cognitive tasks in the elderly. This prospective, placebo-controlled crossover design comprises 24 healthy elderly individuals (mean age 68.8 ± 4.0 years, 17 females) performing a 2-back working memory (WM) task in functional magnetic resonance imaging (fMRI). ⋯ The inverse comparison of placebo versus caffeine had no significant difference. Activation strength of the task-relevant-network component correlated with response accuracy for caffeine yet not for placebo, indicating a selective cognitive effect of caffeine. The present findings suggest that acute caffeine intake enhances WM-related brain activation as well as functional connectivity of blood oxygen level-dependent fMRI in elderly individuals.
-
Randomized Controlled Trial
Reduced nucleus accumbens reactivity and adolescent depression following early-life stress.
Depression is a common outcome for those having experienced early-life stress (ELS). For those individuals, depression typically increases during adolescence and appears to endure into adulthood, suggesting alterations in the development of brain systems involved in depression. Developmentally, the nucleus accumbens (NAcc), a limbic structure associated with reward learning and motivation, typically undergoes dramatic functional change during adolescence; therefore, age-related changes in NAcc function may underlie increases in depression in adolescence following ELS. ⋯ Additionally, functional magnetic resonance imaging results showed atypical NAcc development, where the ELS group did not show a typical increase in NAcc reactivity during adolescence. Consequently, the ELS group showed NAcc hypoactivation during adolescence, and lower NAcc reactivity was correlated with higher depression scores. The results have important implications for understanding how ELS may influence increases in depression via neural development during the transition to adolescence and highlight the importance of identifying at-risk individuals in childhood, a potential critical period for depression-targeted intervention.
-
Randomized Controlled Trial
Illumination influences working memory: an EEG study.
Illumination conditions appear to influence working efficacy in everyday life. In the present study, we obtained electroencephalogram (EEG) correlates of working-memory load, and investigated how these waveforms are modulated by illumination conditions. We hypothesized that illumination conditions may affect cognitive performance. ⋯ The fact that the illumination condition affects brain activity but not behavioral performance suggests that the lighting conditions used in the present study did not influence the performance stage of behavioral processing. Nevertheless, our findings provide objective evidence that illumination conditions modulate brain activity. Further studies are necessary to refine the optimal lighting parameters for facilitating working memory.
-
Randomized Controlled Trial
Stimulus-driven attention modulates the release of anticipatory postural adjustments during step initiation.
Step initiation can be modified by environmental stimulations, suggesting the involvement of stimulus-driven attention. Therefore, we assessed the influence of attentional status during step preparation. ⋯ The cortical integration of an auditory stimulus (as evidenced by the P300 component) in a subject conditioned to initiate gait appears to release postural adjustments via two different attentional mechanisms: an "alerting effect" and an "orienting effect".
-
Randomized Controlled Trial
Correlation between audio-visual enhancement of speech in different noise environments and SNR: a combined behavioral and electrophysiological study.
In the present study, we investigated the multisensory gain as the difference of speech recognition accuracies between the audio-visual (AV) and auditory-only (A) conditions, and the multisensory gain as the difference between the event-related potentials (ERPs) evoked under the AV condition and the sum of the ERPs evoked under the A and visual-only (V) conditions in different noise environments. Videos of a female speaker articulating the Chinese monosyllable words accompanied with different levels of pink noise were used as the stimulus materials. The selected signal-to-noise ratios (SNRs) were -16, -12, -8, -4 and 0 dB. ⋯ The behavioral results showed that the maximum gain as the difference of speech recognition accuracies between the AV and A conditions was at the -12 dB SNR. The ERP results showed that the multisensory gain as the difference between the ERPs evoked under the AV condition and the sum of ERPs evoked under the A and V conditions at the -12 dB SNR was significantly higher than those at the other SNRs in the time window of 130-200 ms in the area from frontal to central region. The multisensory gains in audio-visual speech recognition at different SNRs were not completely accordant with the principle of inverse effectiveness, but confirmed to cross-modal stochastic resonance.