Archives of pathology & laboratory medicine
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Arch. Pathol. Lab. Med. · Oct 2020
Randomized Controlled Trial Multicenter StudyDigital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology.
The adoption of digital capture of pathology slides as whole slide images (WSI) for educational and research applications has proven utility. ⋯ WSIs are noninferior to traditional glass slides for primary diagnosis in anatomic pathology.
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Arch. Pathol. Lab. Med. · Sep 2014
Multicenter Study Comparative StudyTrends in parenteral direct thrombin inhibitor use in pediatric patients: analysis of a large administrative database.
Parenteral direct thrombin inhibitors (DTIs) may be used in pediatric patients with contraindications to heparin therapy, such as heparin-induced thrombocytopenia. Few data exist regarding the use of DTIs in pediatric patients. ⋯ Pediatric use of DTIs is infrequent and occurs in patients with high morbidity and mortality.
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Arch. Pathol. Lab. Med. · Dec 2013
Multicenter Study Comparative StudyMulti-institutional comparison of whole slide digital imaging and optical microscopy for interpretation of hematoxylin-eosin-stained breast tissue sections.
Whole slide imaging (WSI) is now used for educational purposes, for consultation, and for archiving and quantitation of immunostains. However, it is not routinely used for the primary diagnosis of hematoxylin-eosin-stained tissue sections. ⋯ In this study, we demonstrated that WSI and OM have similar accuracy, precision, and reproducibility for interpreting hematoxylin-eosin-stained breast tissue sections. Further clinical studies using routine surgical pathology specimens would be useful to confirm these findings and facilitate the incorporation of WSI into diagnostic practice.
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Arch. Pathol. Lab. Med. · Aug 2005
Multicenter StudyNorth American pretransfusion testing practices, 2001-2004: results from the College of American Pathologists Interlaboratory Comparison Program survey data, 2001-2004.
Pretransfusion testing of whole blood and red blood cell recipients is regulated by the federal government under the authority of the Clinical Laboratory Improvement Amendments of 1988. Regulated tests include determination of ABO group, Rh D type, antibody detection, antibody identification, and crossmatching. A wide variety of methods and reagents are available for these regulated tests. During 2001-2004, the College of American Pathologists (CAP) Interlaboratory Comparison Program (Proficiency Testing) J-Survey collected data from more than 4000 laboratories regarding their pretransfusion testing practices. Those data are presented in this report. ⋯ Most North American laboratories currently favor tube methods when performing ABO grouping, Rh typing, antibody screening, and crossmatching. However, there has been a significant increase in the use of gel-based methods in recent years, especially for antibody detection and crossmatching. Data collection and data analysis of CAP Interlaboratory Comparison Program Survey results allow for assessment of laboratory proficiency and provide insights into current North American practice trends in pretransfusion compatibility testing.
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Arch. Pathol. Lab. Med. · Apr 2003
Multicenter StudyFactors affecting transfusion of fresh frozen plasma, platelets, and red blood cells during elective coronary artery bypass graft surgery.
The ability to predict the use of blood components during surgery will improve the blood bank's ability to provide efficient service. ⋯ Prediction models based on preoperative variables may facilitate blood component management for patients undergoing elective CABG. Algorithms are available to predict transfusion resources to assist blood banks in improving responsiveness to clinical needs. Predictors for use of each blood component may be identified prior to elective CABG for VA patients.