Psychopharmacology
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Randomized Controlled Trial
Human abuse liability assessment of oxycodone combined with ultra-low-dose naltrexone.
Prescription opioid abuse has risen dramatically in the United States as clinicians have increased opioid prescribing for alleviation of both acute and chronic pain. Opioid analgesics with decreased risk for abuse are needed. ⋯ The addition of ultra-low-dose NTX to OXY did not decrease abuse liability of acutely administered OXY in experienced opioid abusers.