Spine
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Whole bovine coccygeal discs were cultured under static load, with or without vertebral endplates (VEPs), and assessed for cell viability, biochemical stability, biosynthetic activity, and biosynthetic responsiveness to changes in mechanical load. ⋯ It is possible to maintain cell viability and the biosynthetic responsiveness of large discs for up to 1 week in vitro when the discs are cultured under static load and without VEP.
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Comparative Study
The reliability and construct validity of the Neck Disability Index and patient specific functional scale in patients with cervical radiculopathy.
Cohort study of patients with cervical radiculopathy undergoing physical therapy. ⋯ Our results suggest that the PSFS exhibits superior reliability, construct validity, and responsiveness in this cohort of patients with cervical radiculopathy compared with the NDI. Further research is needed to examine the ability of these measures to accurately reflect changes in individuals, as well as large samples of patients.
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Multicenter Study
Refinement of the SRS-22 Health-Related Quality of Life questionnaire Function domain.
Prospective observational case series. ⋯ With a minor revision of question 18 (related to going out) the internal consistency of the SRS-22 Function domain has been improved in idiopathic scoliosis patients < 18 years of age. Deletion of question 15 (related to financial considerations) has a variable, small effect depending on patient group. Retention of question 15 is recommended unless a cultural variable, such as differences in healthcare payment schemes, substantially lowers domain psychometric properties.
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Psychometric testing of translated, culturally adapted questionnaire. ⋯ The EABPS-G is a valid, reliable, and responsive questionnaire for assessing health status and disability influenced by pain in one or more area of the spine and allows intercultural comparisons with the original English version. It could be used for assessment of current state as well as measurement for change.
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Randomized Controlled Trial
Minimal clinically important change for pain intensity, functional status, and general health status in patients with nonspecific low back pain.
Cohort study. ⋯ Reporting the percentage of patients who have made a MCIC adds to the interpretability of study results. We present a range of MCIC values and advocate the choice of a single MCIC value according to the specific context.