Spine
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Fibrin sealant (FS) combined with or without growth factor was used to improve the micro-architectural and biomechanical properties of vertebral body in osteoporotic ovine spine. ⋯ The use of bBMP/FS in the treatment of vertebral osteoporosis in an attempt to enhance bone strength merits further study.
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Comparative Study
The outcomes of scoliosis surgery in patients with syringomyelia.
A retrospective review of a consecutive case series. ⋯ The lack of thoracic hypokyphosis seen in idiopathic-like curves is a strong indicator of a possible underlying syrinx. Neurosurgical treatment of the syrinx did not improve the scoliosis. Caution should be exercised when choosing fusion levels, and arthrodesis should be planned with the underlying pathology in mind. Scoliosis surgery has proven to be safe in patients with treated syrinx when spinal cord monitoring or wake-up tests are used.
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Review Comparative Study
Anterior cervical discectomy and fusion associated complications.
Retrospective review study with literature review. ⋯ Meticulous knowledge of the ACDF-associated complications allows for their proper management. Postoperative dysphagia, hematoma, and recurrent laryngeal nerve palsy were the most common complications in our series. Management of complications was successful in the vast majority of our cases.
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Multicenter Study Comparative Study
Pediatric spinal injury type and severity are age and mechanism dependent.
Retrospective case review. ⋯ This study has shown that the pattern of spinal injury in children is related to age and also the mechanism of injury. While traffic-related incidents are a leading cause of injury across all age groups, emphasis on fall prevention is needed for younger children. Older children, particularly boys, are sustaining spinal trauma in sporting and recreational activities.
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Randomized Controlled Trial Multicenter Study Comparative Study
Recombinant activated factor VII in spinal surgery: a multicenter, randomized, double-blind, placebo-controlled, dose-escalation trial.
Randomized, placebo-controlled, double-blind, multicenter, Phase IIa study. ⋯ No safety concerns were indicated for the use of rFVIIa in patients at all doses tested; rFVIIa reduced adjusted blood loss and adjusted transfusions during spinal surgery.