Spine
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Comparative Study
Minimal clinically important change of the Neck Disability Index and the Numerical Rating Scale for patients with neck pain.
Prospective, single-cohort study. ⋯ The estimated MCIC should be used as an indication for relevant changes in clinical practice. Using the optimal cutoff point of the ROC curve, false positives and false negatives are equally weighted; and if there are no objections doing so, the optimal cutoff point of the ROC curve may be a good choice.
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Comparative Study
An outcome measure for Japanese people with chronic low back pain: an introduction and validation study of Japan Low Back Pain Evaluation Questionnaire.
Development of a nationwide patient-based outcome measure for patients with chronic low back pain (CLBP). ⋯ The JLEQ was shown to be a valid and reliable questionnaire scale for measurement of patient-based outcomes in CLBP patients.
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Comparative Study
The role of extracellular factors in human metastatic chordoma cell growth in vitro.
Human metastatic chordoma cells were isolated, and initial in vitro characterization was performed. Biochemical and physiologic changes were observed in response to pH, oxygen, and glucose. ⋯ The level of proliferation, apoptosis, and tyrosine phosphorylation, as well as the overall protein expression profile, strongly depended on extracellular media pH and oxygen/glucose levels. Chordoma's preferred extracellular microenvironment in vitro was rather alkaline, with an optimum at pH 8.5, and apoptotic changes were induced at acidic pH. We found that bovine serum albumin was accumulated by chordoma cells from the incubation media, and this accumulation depended on extracellular pH, with the highest accumulation at alkaline pH.
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Randomized Controlled Trial Multicenter Study Comparative Study
The effects of lifestyle intervention for hypertension on low back pain: a randomized controlled trial.
Randomized controlled trial. ⋯ Multidisciplinary lifestyle intervention aimed to reduce hypertension is not effective at reducing prevalence of low back pain or disability. However, in the subgroup of persons doing moderate or heavy work, the intervention seemed to reduce prevalence of low back pain during the 1-year follow-up.
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Comparative Study
From chronic low back pain to disability, a multifactorial mediated pathway: the InCHIANTI study.
Clinicoepidemiologic study in the Chianti area (Tuscany, Italy). ⋯ The cross-sectional association between LBP and self-reported disability, in specific tasks is modulated by performance measures. Specific performance-based tests that explore the functional consequences of LBP may help design specific interventions of disability prevention and treatment in patients with LBP.