Spine
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Retrospective analysis using kinetic magnetic resonance images (MRIs). ⋯ The present study demonstrated that the changes in sagittal alignment of the cervical spine affect the kinematics. Consequently, it may cause changes in the segment subjected to maximum load for overall motion and accelerate its degeneration.
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Technical note. ⋯ A surgical technique for the replacement of vertebral body by posterior approach is presented. This technique could be used in surgery of vertebral body tumors of the lumbar spine, in a single surgical approach.
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Retrospective review of an anterior polyetheretherketone (PEEK) cage incorporated with a bovine xenograft to treat disorders of the cervical disc. ⋯ As applied in anterior cervical fusion, the cage incorporated with the xenograft prevented donor-site morbidity and provided successful fusion.
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Molecular biologic and immuno-histologic analyses using in vitro murine intervertebral disc tissue culture. ⋯ TWEAK plays an important role in MMP-3 induction in murine disc cells via JNK that results in degradation of disc matrix. TWEAK also induces MCP-1, which belongs to the chemokine family that recruits inflammatory cells via the NF-kappaB pathway.
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DNA array analysis of dorsal root ganglion (DRG) using a rat model with nerve root constriction. ⋯ The genes identified in this study, especially those involved in pain signaling and inflammation, serve as potential targets for molecular-based therapy for lumbar radiculopathy.