Spine
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The twy/twy mouse undergoes spontaneous chronic mechanical compression of the spinal cord; this in vivo model system was used to examine the effects of retrograde adenovirus (adenoviral vector [AdV])-mediated brain-derived neurotrophic factor (BDNF) gene delivery to spinal neural cells. ⋯ Our results demonstrate that targeted retrograde BDNF gene delivery suppresses apoptosis in neurons and oligodendrocytes in the chronically compressed spinal cord of twy/twy mouse. Further work is required to establish whether this method of gene delivery may provide neuroprotective effects in other situations of compressive spinal cord injury.
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Review Case Reports
Massive vertebral destruction associated with chronic rupture of infrarenal aortic aneurysm: case report and systematic review of the literature in the English language.
Case report and review of literature. ⋯ The presence of aortic abdominal aneurysm is always to be considered in the evaluation of an elderly patient complaining lower back pain or lower limb neuropathy of recent onset, especially in the presence of a degenerative process of the spine.
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A prospective single-arm trial. ⋯ Our study shows that 10 weeks of dynamic isolated training of the lumbar extensors, once a week, leads to clinically relevant improvements in functional status of men with CNSLBP, without accompanying improvements in functional cross-sectional area of LM. These findings suggest that improvement in LM morphology is not a critical success factor in restoring functional status of patients with CNSLBP, at least in the short term (6 mo).
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Case report and literature review. ⋯ In adolescents, if the history and physical examination are consistent with a clay-shoveler's fracture, but radiographs are normal, magnetic resonance imaging may be indicated to diagnose a soft-tissue avulsion.
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Validity and reliability of a back pain questionnaire. ⋯ The study showed that the psychometric properties of the original QDS have been preserved when translated into Arabic and can be used to measure disability in Arabic societies.