Spine
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An ambispective cohort study. ⋯ 4.
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Pedicle subtraction osteotomy (PSO) can provide major sagittal correction for adult spinal deformity, sometimes achieving correction greater than 30°. Surgeons have reported failure rates up to 30% within 2 years, increasing to 46% after 4 to 5 years (SDC Figure 1, http://links.lww.com/BRS/B87). ⋯ PSO has achieved positive outcomes, but when used to correct posture in older patients with spinal deformity and fixed sagittal imbalance, rod breakage often leads to multiple surgical revisions. These complications must be avoided.
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Researchers are seeking ways to heal bone better and faster. Cellular grafts can accelerate bone healing and promote bone formation. Immediately after injury, blood clot formation yields inflammatory cells; an influx of mesenchymal stem cells (MSCs) and osteogenic cells follows. ⋯ Osteoinduction stimulates stem cells to differentiate into osteoblasts and promotes cell migration. Osteoinductive agents include demineralized bone matrices () and bone morphogenetic proteins, which are extremely potent but are associated with risks and high costs. Amniotic tissue is relatively unregulated and has strong anti-inflammatory effects but has not been well studied in relation to bone formation and healing.
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A retrospective study. ⋯ 3.
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Case Reports
Worsening Cervical Epidural Hematoma After Tissue Plasminogen Activator Administration For Stroke Like Symptoms.
Case report. ⋯ 5.