Spine
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Retrospective Cohort Study. ⋯ 3.
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Retrospective study. ⋯ 3.
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Porcine intervertebral discs (IVDs) were excised and then drilled to simulate degeneration before being electrically stimulated for 21 days while undergoing mechanical loading. The discs were then analyzed for gene expression and morphology to assess regeneration. ⋯ The direct electrical stimulation application in NP of damaged IVDs can be a viable option to regenerate damaged NP and annulus fibrosus tissues.
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Controlled, randomized, animal study. ⋯ Melatonin alleviates radicular pain from LDH by inhibiting central sensitization via binding with its receptor 2, decreasing spinal CGRP, IB4, and NR2B expression.
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Retrospective cohort study. ⋯ LSS patients insured through Medicaid have systematically worse baseline PROMs across almost all domains as compared to those with commercial insurance and Medicare, even after adjusting for confounders. These findings have broad ranging implications for research and healthcare policy, especially when using PROMs as measures of value.