Spine
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Genome-wide association study (GWAS) meta-analysis with downstream analyses. ⋯ Level 3 (observational study).
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Meta-Analysis. ⋯ Among patients with thoracolumbar fractures, treatment with MIS was associated with decreased EBL, shorter LOS, earlier pain reduction, and less regional kyphosis compared to treatment with open fixation. Additionally, higher radiation-exposure was seen among patients treated with MIS. While MIS offers several potential benefits, both MIS and open fixation remain safe and reliable options for the treatment of thoracolumbar fractures.
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Prospective trial comparing the investigation group to propensity-matched historic control group. ⋯ PEEK-on-ceramic TDR produced significantly improved outcomes maintained throughout five-year follow-up that were similar or superior to ACDF, supporting TDR in appropriately selected patients.
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Cohort study. ⋯ Level III.