Spine
-
Comparative Study
Stage-specific sagittal spinopelvic alignment changes in osteoarthritis of the hip secondary to developmental hip dysplasia.
A retrospective, age- and sex-matched radiographic study. ⋯ Pelvic inclination tended to increase in pre/early-stage OA patients. In healthy subjects, aging is associated with reduction of lumbar lordotic angle and tendency for posterior inclination of the sacrum. With aging, patients with OA maintained the lumbar lordotic angle and did not develop a posterior sacral slope angle.
-
Comparative Study
The role of extracellular factors in human metastatic chordoma cell growth in vitro.
Human metastatic chordoma cells were isolated, and initial in vitro characterization was performed. Biochemical and physiologic changes were observed in response to pH, oxygen, and glucose. ⋯ The level of proliferation, apoptosis, and tyrosine phosphorylation, as well as the overall protein expression profile, strongly depended on extracellular media pH and oxygen/glucose levels. Chordoma's preferred extracellular microenvironment in vitro was rather alkaline, with an optimum at pH 8.5, and apoptotic changes were induced at acidic pH. We found that bovine serum albumin was accumulated by chordoma cells from the incubation media, and this accumulation depended on extracellular pH, with the highest accumulation at alkaline pH.
-
Case report. ⋯ The early fusion prevented the customary severe progression of this condition and early death due to cor pulmonale. He is a fully functioning member of society. Will more modern treatments with lengthening of the hemithorax provide a better outcome? Only time will tell.
-
Multicenter Study
Minimal clinically important change for pain intensity and disability in patients with nonspecific low back pain.
Cohort study. ⋯ In subacute and chronic patients, improvements in LBP of
-
Survey. ⋯ Routine sedation does not seem to be required for patients receiving spinal injections, but more-anxious patients benefit from sedation before an injection. Benzodiazepams are effective in controlling anxiety for the majority of patients.