Spine
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Case report. ⋯ The early fusion prevented the customary severe progression of this condition and early death due to cor pulmonale. He is a fully functioning member of society. Will more modern treatments with lengthening of the hemithorax provide a better outcome? Only time will tell.
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Multicenter Study
Minimal clinically important change for pain intensity and disability in patients with nonspecific low back pain.
Cohort study. ⋯ In subacute and chronic patients, improvements in LBP of
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Survey. ⋯ Routine sedation does not seem to be required for patients receiving spinal injections, but more-anxious patients benefit from sedation before an injection. Benzodiazepams are effective in controlling anxiety for the majority of patients.
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Human nucleus pulposus cells were cultured in alginate beads and activated with IL-1 beta or TNF-alpha, with and without inhibition of p38 mitogen activated protein kinase (p38 MAPK) activity. Cell production of factors modulating the anabolic/catabolic balance of the disc was determined. ⋯ Inhibition of p38 MAPK in cytokine-activated disc cells blunts production of factors associated with inflammation, pain, and disc matrix catabolism. The data support further analysis of these effects on the anabolic/catabolic balance of nucleus pulposus cells and suggest that molecular techniques blocking this signal could provide a therapeutic approach to slow the course of intervertebral disc degeneration.
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A retrospective study. ⋯ The line Tr, (runs perpendicular to the line which passes the bilateral transverse processes) had the greatest correlation to the rotation of a vertebra. On the other hand, the line Sp (defined as the midline of the spinous process) was not sufficient for predicting rotation of a vertebra and can be disregarded during the intraoperative analysis and screw placement.